Uses
Symbyax may be prescribed for the treatment of the depressive phase of bipolar disorder. However, Symbyax has not gained much traction and has and has largely fallen out of favor with psychiatrists since there is no way to titrate separately the individual ingredients. It is now much more common to use a combination of lamotrigine (Lamictal) with lithium if lamotrigine alone is not effective. If there is a need for further treatment, the addition of a second-generation medication, such as Vraylar or Latuda or Rexulti, is often used instead. Virtually all patients with this disorder experience the depressive phase commonly referred to as bipolar depression. People with bipolar disorder typically have three times as many depressed days than they do manic days over the course of their illness. Symbyax can also now be prescribed for treatment-resistant depression.
Common Side Effects
Common side effects that may go away with time include:
Appetite increaseWeight gainDry mouthDiarrheaLosing or not having strengthSexual difficulties, including decreased interest or inability to orgasmErectile dysfunctionTwitchingJoint swelling, redness or pain
If any of these side effects don’t go away or cause problems, be sure to tell your doctor.
Potentially Serious Side Effects
If you have any of the following side effects, it’s important to contact your doctor right away as you may need medical treatment. These potentially serious side effects include:
CongestionRunny noseCoughTingling in your hands or feetDementiaDelusionsBody aches or painGaining weight suddenlyDifficulty swallowingSwelling in your arms, legs, hands, feet, or faceDifficulty breathing or speakingMemory problemsChest tightnessVision changesIrregular heartbeatDizziness
Research
According to a study done around the time Symbyax was approved by the FDA, Symbyax helped to treat the symptoms of bipolar depression more effectively and at a significantly faster rate than placebo. In the eight-week studies, patients in the Symbyax group experienced significantly greater improvement in depressive symptoms compared with patients taking a placebo. That robust symptom improvement was sustained throughout the entire eight weeks of the study. In addition, Symbyax patients had no statistically greater risk of treatment-emergent mania than patients taking a placebo. A more recent study that looked at a series of other studies regarding Symbyax also showed its continued effectiveness in treating and keeping the depressive episodes of bipolar disorder at bay. The only concern was that the side effects may be worse when using Symbyax than they are with other medications, particularly weight gain.
Discuss Your Medical History With Your Doctor
If you are considering starting Symbyax, discuss your medical history with your healthcare provider. Be sure to tell your doctor if any of the following apply:
You are currently taking any medications You are taking Prozac (fluoxetine) or Zyprexa (olanzapine) You are taking or plan to take nonsteroidal anti-inflammatory drugs or aspirin You are pregnant or plan to become pregnant You are breastfeeding or plan to breastfeed You are older than 65 and have dementia You have high blood sugar, diabetes or a family history of diabetes You have liver problems You have seizures You have high or low blood pressure You have heart problems You have had a stroke You have an enlarged prostate You have an eye problem called narrow-angle glaucoma You have a stomach problem called paralytic ileus You currently smoke You drink alcohol You exercise often
